Possible Research Trail for Knowledge-base
Fauci as well as representatives of the Gates Foundation, the Chinese CDC, and representatives of other nations sit on the board of the Global Preparedness Monitoring Board (GPMB). They worked to create a report that discussed the deliberate release of a lethal respiratory pathogen. The GPMB was assembledin 2019 in response to a request from the office of the U.N. secretary-general and the W.H.O. and created its report in September 2019: "A World At Risk - Annual Report on Global Preparedness for Health Emergencies." See:
Selected Journal Articles with Research Done by the Chinese Scientist they call, "the Bat Lady," Shi Zhengli
Differential stepwise evolution of SARS coronavirus functional proteins in different host species.
Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins.
We are told that the organs with the most ACE2 receptors are where the virus most attacks people
Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry
Hmm. Key amino acids needed for SARS Coronavirus to attach to ACE2 receptors They just need to understand these things for the good of the world, don't they! Or to kill people?
Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
"Understanding the bat origin of human coronaviruses is helpful for the prediction and prevention of another pandemic emergence in the future."
Coronavirus: epidemiology, genome replication and the interactions with their hosts.
Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses
Acknowledgements This work was supported by the National Natural Science Foundation of China (81290341, 31621061 to Zheng-Li Shi), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDPB0301 to Zheng-Li Shi), National Institute of Allergy and Infectious Diseases of National Institutes of Health grant (R01AI110964 to Zheng-Li
Shi), the National Key Research and Development Program of China (2016YFC1201000 to Shibo Jiang) and NIH grant (R01AI098775 to Shibo Jiang and Lanying Du)
Virol Sin. 2018 Feb;33(1):104-107. doi: 10.1007/s12250-018-0012-7. Epub 2018 Mar 2.
Wang N1,2, Li SY3, Yang XL1, Huang HM3, Zhang YJ1, Guo H1,2, Luo CM1,2, Miller M4, Zhu G4, Chmura AA4, Hagan E4, Zhou JH5, Zhang YZ5,6, Wang LF7, Daszak P4, Shi ZL8. PMID: 29500691 PMCID: PMC6178078 DOI: 10.1007/s12250-018-0012-7
"This study was jointly funded by the National Natural Science Foundation of China Grant (81290341) to ZLS; the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Number R01AI110964) to PD and ZLS [Shi Zhengli], United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT project Grant (Cooperative Agreement No. AID-OAA-A-14-00102) to PD; and Singapore NRF-CRP Grant (NRF2012NRF-CRP001–056) and CD-PHRG Grant (CDPHRG/0006/2014) to LFW."
" Our study expands the host ranges of MERS-related CoV and represents an important step toward establishing bats as the natural reservoir of MERS-CoV. These findings may lead to improved epidemiological surveillance of MERS-CoV and the prevention and control of the spread of MERS-CoV to humans."
Acknowledgements: We thank Lanying Du for the mouse antiserum and monoclonal antibody against MERS-CoV-spike. This study was jointly funded by the Scientific and Technological Basis Special Project (2013FY113500) from the Ministry of Science and Technology of the People's Republic of China to Z.-L.S., a USAID Emerging Pandemic Threats PREDICT project grant (Cooperative Agreement no. AID-OAA-A-14-00102), NIH grants (R01AI110964 to Z.-L.S. [Shi Zhengli] ; R01AI089728 and R01AI110700 to F.L.), and the National Natural Science Foundation of China (31727901) to Z.-L.S.
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses [meaning from bats to other species], as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.
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