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Possible Research Trail for Knowledge-base
to be able to Develop SARS CoV-2 or a similar Virus
Is this what was done? Perhaps we will never know

We do know that Dr Anthony Fauci financed some of the research through the US NIAID grants to Univ of N Carolina Chapel Hill and later to EcoHealth that was diverted to Wuhan Institute of Virology. See the actual grants here: https://www.hospicepatients.org/fauci-niaid-grant-to-ecohealth-to-wuhan-institute-of-virology-laboratory-2014-2019.pdf
originally posted at: https://taggs.hhs.gov/Detail/AwardDetail?arg_AwardNum=R01AI110964&arg_ProgOfficeCode=104

Why would Dr Fauci fund "gain of function" research? Was it to prevent a pandemic and simply create a vaccine? His associations with Bill Gates and the "Bill and Melinda Gates Foundation" are very strong and involve millions in donations to the NIH, the W.H.O., and other organizations that Fauci participates in as a board member. The Gates Foundation has funded several vaccine manufacturers at the same time he is pushing for global mandatory vaccination of every person on Earth.

Fauci as well as representatives of the Gates Foundation, the Chinese CDC, and representatives of other nations sit on the board of the Global Preparedness Monitoring Board (GPMB). They worked to create a report that discussed the deliberate release of a lethal respiratory pathogen. The GPMB was assembledin 2019 in response to a request from the office of the U.N. secretary-general and the W.H.O. and created its report in September 2019: "A World At Risk - Annual Report on Global Preparedness for Health Emergencies." See: www.hospicepatients.org/global-preparedness-monitoring-board-gpmb-sept-2019-report-requested-by-un-who-release-of-lethal-resp-pathogen-plandemic.pdf

We do know that Gates and many other elites have often expressed their dedication to global vaccination programs, depopulation, eugenics, and a more authoritarian global governmental model.

Selected Journal Articles with Research Done by the Chinese Scientist they call, "the Bat Lady," Shi Zhengli

Just the titles give us insight into the general trend of her research but read them for yourself if you wish. There are dozens and dozens more that were done, but this presents a picture of how scientific knowledge has been advanced. This knowledge can clearly be used to save lives, to create vaccines, to understand disease, but might have another use known as "dual use" applications.


Differential stepwise evolution of SARS coronavirus functional proteins in different host species.
BMC Evol Biol. 2009 Mar 5;9:52. doi: 10.1186/1471-2148-9-52.
Tang X1, Li G, Vasilakis N, Zhang Y, Shi Z, Zhong Y, Wang LF, Zhang S.

There's been a lot of discussion of the "Spike" protein where the virus attaches within the cell. Understanding that is necessary for the creation of a virus that will infect a human.

Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins.
Biochem Biophys Res Commun. 2009 Sep 18;387(2):326-9. doi: 10.1016/j.bbrc.2009.07.025. Epub 2009 Jul 16.
Zhou P1, Han Z, Wang LF, Shi Z.


We are told that the organs with the most ACE2 receptors are where the virus most attacks people

Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry
Arch Virol. 2010 Oct;155(10):1563-9. doi: 10.1007/s00705-010-0729-6. Epub 2010 Jun 22. Hou Y1, Peng C, Yu M, Li Y, Han Z, Li F, Wang LF, Shi Z.

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.
J Gen Virol. 2010 Apr;91(Pt 4):1058-62. doi: 10.1099/vir.0.016378-0. Epub 2009 Dec 16. Yuan J1, Hon CC, Li Y, Wang D, Xu G, Zhang H, Zhou P, Poon LL, Lam TT, Leung FC, Shi Z.

Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 [ACE2] to function as a receptor for severe acute respiratory syndrome coronavirus
J Gen Virol. 2010 Jul;91(Pt 7):1708-12. doi: 10.1099/vir.0.020172-0. Epub 2010 Mar 24.
Yu M1, Tachedjian M, Crameri G, Shi Z, Wang LF.

Hmm. Key amino acids needed for SARS Coronavirus to attach to ACE2 receptors They just need to understand these things for the good of the world, don't they! Or to kill people?


Identification of immunogenic determinants of the spike protein of SARS-like coronavirus.
Zhou P1, Han Z, Wang LF, Shi Z.
Virol Sin. 2013 Apr;28(2):92-6. doi: 10.1007/s12250-013-3292-y. Epub 2013 Apr 11.


Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
J Virol. 2015 Sep;89(17):9119-23. doi: 10.1128/JVI.01279-15. Epub 2015 Jun 10. Yang Y, Liu C, Du L, Jiang S, Shi Z, Baric RS, Li F.

Bat origin of human coronaviruses.
Virol J. 2015 Dec 22;12:221. doi: 10.1186/s12985-015-0422-1.
Hu B1, Ge X1, Wang LF2, Shi Z3.

"Understanding the bat origin of human coronaviruses is helpful for the prediction and prevention of another pandemic emergence in the future."



Coronavirus: epidemiology, genome replication and the interactions with their hosts.
Virol Sin. 2016 Feb;31(1):1-2. doi: 10.1007/s12250-016-3746-0.
Shi ZL1, Guo D2, Rottier PJ3.


Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses
Sci China Life Sci. 2017 Dec;60(12):1399-1402. doi: 10.1007/s11427-017-9189-3. Epub 2017 Nov 10. PMID: 29134417 PMCID: PMC7089274 DOI: 10.1007/s11427-017-9189-3
Zeng LP1, Ge XY1, Peng C1, Tai W2, Jiang S2,3, Du L4, Shi ZL5.

"... our results have demonstrated that most SARS-CoV RBD-specific antibodies tested in this study could cross-neutralize SL-CoV strain WIV1, but not SHC014. While SARS-CoV and WIV1 have comparable RBD, the RBD of SHC014 is much more variable, as previously noted (Figure S1 in Supporting Information). More specifically, the RBD of SHC014 has a difference of 24 amino acids (aa) compared to that of SARS-CoV, while the RBD of WIV1 only has a difference of 8 aa. This may explain why SHC014 could not be cross-neutralized effectively by most antibodies (mAbs or pAbs) targeting SARS-CoV RBD.

The fact that SHC014 retains its ability to infect human cells implies that the available antibodies and vaccines based on SARS-CoV RBD will not protect the next SARS-like disease caused by bat SL-CoV SHC014 strain. Thus, further development of effective vaccines and treatments for potential infection by the SL-CoV strains, as represented by SHC014, is urgently needed.

Acknowledgements This work was supported by the National Natural Science Foundation of China (81290341, 31621061 to Zheng-Li Shi), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDPB0301 to Zheng-Li Shi), National Institute of Allergy and Infectious Diseases of National Institutes of Health grant (R01AI110964 to Zheng-Li

Shi), the National Key Research and Development Program of China (2016YFC1201000 to Shibo Jiang) and NIH grant (R01AI098775 to Shibo Jiang and Lanying Du)


Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China.

Virol Sin. 2018 Feb;33(1):104-107. doi: 10.1007/s12250-018-0012-7. Epub 2018 Mar 2.

Wang N1,2, Li SY3, Yang XL1, Huang HM3, Zhang YJ1, Guo H1,2, Luo CM1,2, Miller M4, Zhu G4, Chmura AA4, Hagan E4, Zhou JH5, Zhang YZ5,6, Wang LF7, Daszak P4, Shi ZL8. PMID: 29500691 PMCID: PMC6178078 DOI: 10.1007/s12250-018-0012-7


"This study was jointly funded by the National Natural Science Foundation of China Grant (81290341) to ZLS; the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (Award Number R01AI110964) to PD and ZLS [Shi Zhengli], United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT project Grant (Cooperative Agreement No. AID-OAA-A-14-00102) to PD; and Singapore NRF-CRP Grant (NRF2012NRF-CRP001–056) and CD-PHRG Grant (CDPHRG/0006/2014) to LFW."

Discovery of Novel Bat Coronaviruses in South China That Use the Same Receptor as Middle East Respiratory Syndrome Coronavirus
J Virol. 2018 Jun 13;92(13). pii: e00116-18. doi: 10.1128/JVI.00116-18. Print 2018 Jul 1.
Luo CM, Wang N, Yang XL, Liu HZ, Zhang W, Li B, Hu B, Peng C, Geng QB, Zhu GJ, Li F, Shi ZL.

" Our study expands the host ranges of MERS-related CoV and represents an important step toward establishing bats as the natural reservoir of MERS-CoV. These findings may lead to improved epidemiological surveillance of MERS-CoV and the prevention and control of the spread of MERS-CoV to humans."

Acknowledgements: We thank Lanying Du for the mouse antiserum and monoclonal antibody against MERS-CoV-spike. This study was jointly funded by the Scientific and Technological Basis Special Project (2013FY113500) from the Ministry of Science and Technology of the People's Republic of China to Z.-L.S., a USAID Emerging Pandemic Threats PREDICT project grant (Cooperative Agreement no. AID-OAA-A-14-00102), NIH grants (R01AI110964 to Z.-L.S. [Shi Zhengli] ; R01AI089728 and R01AI110700 to F.L.), and the National Natural Science Foundation of China (31727901) to Z.-L.S.


Origin and evolution of pathogenic coronaviruses
Nat Rev Microbiol. 2019 Mar;17(3):181-192. doi: 10.1038/s41579-018-0118-9.
Cui J, Li F, Shi ZL [Shi Zhengli] .


Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses [meaning from bats to other species], as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.

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